The nano particle drug carriers’:
Cancer is a dangerous disease. It had no treatment in the beginning but later studies proved many treatments including nano particle drug carriers’ treatment .Cancer derived from the word Oncology which deals with the branch of medicines in which the preservation, diagnosis as well as treatment of cancer are studied.
The cancer treatment includes surgery and uses of modern technology such as:
- Chemo therapy
- Hormonal therapy
- Radiation therapy
- Adjuvant therapy
- Immune therapy
The nano particle drug carrier only affect the cancerous cells while the other treatments not only affect the cancer cells but also affected normal cells so we use other treatments such as:
- Growth signal inhibitors.
- Drugs that induce apoptosis.
- Nano particle drug carriers.’
- Endogenous angioinhibitor.
- RNA expression profiling and proteomics.
Nano particals drug carriers’ is the most effective treatment.
The effective treatment is the nano particals drug carriers’ treatment .
This is due to the reason because all other methods damaging normal cells with cancerous cells. Nano particals drug carriers ’method for the treatment is also called the Targeted drug delivery system. In this system drugs effect on the more accurate location of tumor. This system improves the pharmacological as well as therapeutic properties of cancer treatment. The new technology has obviously raise safety and efficiency through the use of built protein corona shield through regulating the interfaces between nanoparticals and biological system.
Mechanism of action of nano particle drug carriers’:
Nano particle drug carriers’ are the method that selectively transports drugs to targeted tissues, organs, and cells through a variety of drugs carrier. Many other cancer treatment effects discovered but their effect is minimal. This is because hundreds of proteins in the body stick to the drug delivery system (protein corona phenomenon). Because of this phenomenon, when the drug reaches to the target such as a cancer cell, the treatment efficiency become low, and other side effects appear, which may cause toxic side effects.
The research team introduced the protein corona shield (PCS) concept for an efficient nano partical drug carriers’ treatment.
Team has created recombination fusion proteins using recombinant DNA technology. This fusion protein,act as a shield to encapsulate the surface of nanoparticle drug carriers’, thus constructing PCS nanoparticles (PCSNs).
In principle, nanoparticle drug carriers’ with a target legend lose their targeting ability covered by blood proteins in a biological environment. By mononuclear phagocyte system we avoid unwanted clearance. So the new PCS system can inhibit blood protein adsorption to maintain targeting ability…
To understand the interactions between PCSNs and external biological components, the research team has created an environment similar to human biological systems. The results showed about 10 times greater therapeutic efficacy.
They also examined the effect of nanoparticals drug carriers’ by using immune cells and cancer cells. The PCS drug delivery system kill cancer cells without attack by immune cells, even after long-term exposure to biological environments. The team found that the PCSN exhibit lower toxicity, as well as excellent tumor-targeting ability.
Nanoparticles drug carriers’ treatments
(1)Nan particle drug carriers’ Chemotherapy
- The nanoparticle use in this treatment is CRLX101 is called Cerulean Pharma.
- In laboratory mice studies the IPA-3 appears to reduce the growth of prostate cancer cells.
- Researches’ are testing the use of chemotherapy drug combination stays in the tumor longer than the chemotherapy drug by itself, which should increase the effectiveness.
(2) Nanoparticles drug carriers’ by Heat:
Nanoparticles drug carriers’ called AuroShells absorb infrared light from a laser, turning the light into heat.